منابع مشابه
Adult-onset cerebral folate deficiency.
OBJECTIVE To report new manifestations of cerebral folate deficiency, a rare metabolic autoimmune syndrome,in an adult. DESIGN Case report. SETTING University teaching hospital. PATIENT A 58-year-old woman with progressive memory loss and myoclonus presented for medical attention. Results of cerebral spinal fluid analysis showed low levels of tetrahydrobiopterin and 5-methyltetrahydrofola...
متن کاملCerebral folate deficiency syndrome.
to the editor: Ramaekers et al. (May 12 issue)1 report 28 patients with the cerebral folate deficiency syndrome characterized by decreased levels of 5-methyltetrahydrofolate (5MTHF) in the cerebrospinal fluid caused by autoantibodies’ blocking of folate transport into the brain. The patients benefited from folinic acid supplementation. The clinical features of this syndrome fit with other neuro...
متن کاملCerebral folate deficiency.
Cerebral folate deficiency (CFD) can be defined as any neurological syndrome associated with low cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF), the active folate metabolite, in the presence of normal folate metabolism outside the nervous system. CFD could result from either disturbed folate transport or from increased folate turnover within the central nervous system (CNS). We repo...
متن کاملAutoantibodies against Folate Receptors and the Infantile-Onset Cerebral Folate Deficiency Syndrome
From the Division of Pediatric Neurology, Department of Pediatrics, University Hospital Aachen, Aachen, Germany (V.T.R., T.O.); the Department of Medicine, State University of New York Downstate Medical Center, Brooklyn (S.P.R., J.M.S., E.V.Q.); the Division of Clinical Chemistry and Biochemistry, University Children’s Hospital, Zurich, Switzerland (T.O., N.B.); and the Vitamin Metabolism and A...
متن کاملAutoantibodies to folate receptors in the cerebral folate deficiency syndrome.
In infantile-onset cerebral folate deficiency, 5-methyltetrahydrofolate (5MTHF) levels in the cerebrospinal fluid are low, but folate levels in the serum and erythrocytes are normal. We examined serum specimens from 28 children with cerebral folate deficiency, 5 of their mothers, 28 age-matched control subjects, and 41 patients with an unrelated neurologic disorder. Serum from 25 of the 28 pati...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2012
ISSN: 0003-9942
DOI: 10.1001/archneurol.2011.3036